Helping others sleep better every night!
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One of the world’s first laboratories devoted solely to research on how sleep and biological rhythms influence depression, substance abuse, and other aspects of mental well-being, has opened at the University of Michigan Health System (U-M).
The U-M Sleep & Chronophysiology Laboratory welcomed the first research volunteers to its new eight-bed facility this month, and is seeking many more participants for a number of research studies.
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Patients who snore or have other symptoms of sleep apnea often undergo testing in a sleep laboratory to measure the number of breathing pauses and arousals that occur while they slumber. But doctors find these tests do not effectively predict daytime consequences suspected to arise from sleep apnea, such as sleepiness in adults or hyperactivity in children.
Now, neurologists at the University of Michigan Health System and engineers at Altarum Institute in Ann Arbor, Mich., have discovered evidence that the disruption of sleep in sleep apnea may be much more frequent than the breathing pauses, or apneas, themselves.
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Researchers who had bred a group of mice in hopes of learning more about a brain hormone that stimulates appetite got a bit of a surprise when they saw that the rodents would suddenly collapse and fall fast asleep with no provocation. As a result, Howard Hughes Medical Institute investigator Masashi Yanagisawa and colleagues at the University of Texas’ Southwestern Medical Center in Dallas have an exciting new lead into the genesis of sleep and the origins of narcolepsy, a severe sleep disorder in humans.
In 1998, Yanagisawa discovered the orexins, small brain proteins and their receptors that regulate feeding behavior in mice. To probe the role that orexins play in regulating appetite, Yanagisawa and his colleagues developed a strain of knockout mice whose orexin genes do not function properly.
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