Metabolic disorders such as obesity and diabetes appear to share risk factors with and may influence the development of Alzheimer’s disease and other forms of dementia, according to several reports published in the March 2009 issue of Archives of Neurology, one of the JAMA/Archives journals.
Women with the cluster of cardiovascular risk factors known collectively as the metabolic syndrome appear likely to develop cognitive impairment over a four-year period. Kristine Yaffe, M.D., of the University of California, San Francisco, and the San Francisco Veterans’ Affairs Medical Center, and colleagues assessed 4,895 older women (average age 66.2) who did not have cognitive impairment at the beginning of the study.
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Not only is obstructive sleep apnea linked to insulin resistance and liver disease independent of obesity, but at least one risk factor is also common to obesity and obstructive sleep apnea: prolonged daytime sitting or standing. Even when the sedentary lifestyle does not lead to obesity, it may still lead to obstructive sleep apnea and its concomitant health risks, according to a research article in the American Journal of Respiratory and Critical Care Medicine.
“Overnight fluid displacement from legs, related to prolonged sitting, may play a previously unrecognized role in the pathogenesis of obstructive sleep apnea,” wrote principle investigator, T. Douglass Bradley, M.D., professor of medicine and director of the Centre for Sleep Medicine and Circadian Biology at the University of Toronto.
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